The study was planned to investigate whether the technique of Solid Dispersions would be helpful for enhancing the dissolution of Piroxicam. Solid dispersions of Piroxicam were prepared by solvent evaporation method using carriers such as Sodium Starch Glycolate, Croscarmellose Sodium. Solid dispersions were characterized by differential scanning calorimeter, X-ray diffractometer and evaluated for dissolution profiles of Piroxicam. A marked increase in dissolution rate was observed with all solid dispersions. Among the carriers studied sodium starch glycolate gave the highest improvement in dissolution rate. Selected dispersions were subjected to stability studies.
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